Liste des publications

Articles originaux et revues publiés dans des périodiques à comité de lecture

Articles originaux

  1. LHERMIE G., F. EL GARCH, P-L TOUTAIN, A.A. FERRAN and A. BOUSQUET-MELOU. Bacterial species-specific activity of a fluoroquinolone against two closely related Pasteurellaceae with similar MICs. Differential in vitro inoculum effects and in vivo efficacies.

    PLOS ONE,accepté, 2015.
  2. COLLET S.H., N. PICARD-HAGEN, M.Z. LACROIX, S. PUEL, C. VIGUIE, A. BOUSQUET-MELOU, P-L TOUTAIN and V. GAYRARD. Allometric scaling for predicting human clearance of bisphenol A.

    Toxicol. Appl. Pharmacol.,284, 323-329, 2015.
  3. FERRAN A.A., P-L TOUTAIN and A. BOUSQUET-MELOU. Comparison of the reduction of the antibacterial potency of a fluoroquinolone conferred by a single mutation in the QRDR or by the inoculum size effect.

    Inter. J. Antimicrob. Agents., 44, 472-474, 2014. article en ligne
  4. VASSEUR M., M. LAURENTIE, J-G ROLLAND, A. PERRIN-GUYOMARD, J. HENRI, A.A. FERRAN, P-L TOUTAIN and A. BOUSQUET-MELOU. Low or high doses of cefquinome targeting low or high bacterial inocula cure Klebsiella pneumonia lung infections but differentially impact the levels of antibiotic resistance in fecal flora.

    Antimicrob. Agents Chemother., 58, 1744-1748, 2014. article en ligne
  5. REY J. F., C. M. LAFFONT, S. CROUBELS, P. DE BACKER, C. EMIRLINE, E. BOUSQUET, J. GUYONNET, A. A. FERRAN, DVM1, A. BOUSQUET-MELOU and P.-L. TOUTAIN. Use of Monte Carlo simulation to examine pharmacodynamic cut-off values of amoxicillin to establish a breakpoint for antimicrobial susceptibility testing in pigs.

    Am. J. Vet. Res., 75, 127-131, 2014.
  6. GAYRARD V., M. Z. LACROIX, S. H. COLLET, C. VIGUIE, A. BOUSQUET-MELOU, P.-L. TOUTAIN, and N. PICARD-HAGEN. Interpreting bisphenol a absorption in the canine oral cavity: Gayrard et al. Respond.

    Environ. Health Perspect., 121, A323-A324, 2013.
  7. FERRAN A.A., D. BIBBAL, T. PELLET, M. LAURENTIE, M. GICQUEL-BRUNEAU, P. SANDERS, M. SCHNEIDER, P-L TOUTAIN and A. BOUSQUET-MELOU. PK/PD assessment of the effects of the parenteral administration of a fluoroquinolone on the intestinal flora: comparison of the bactericidal activity at the gut versus systemic level in a pig model.

    Inter. J. Antimicrob. Agents., 42, 429-435, 2013. article en ligne
  8. DIALLO A.A., H. BRUGERE, M. KEROUDERAN, V. DUPOUY, P.-L. TOUTAIN, A. BOUSQUET-MELOU, E. OSWALD and D. BIBBAL. Persistence and prevalence of pathogenic and extended-spectrum beta-lactamase-producing Escherichia coli in municipal wastewater treatment plant receiving slaughterhouse wastewater.

    Water Res., 47, 4719-4729, 2013.
  9. GAYRARD V., M. Z. LACROIX, S. H. COLLET, C. VIGUIE, A. BOUSQUET-MELOU, P.-L. TOUTAIN, and N. PICARD-HAGEN. High Bioavailability of Bisphenol A from Sublingual Exposure.

    Environ. Health Perspect., 121, 951-956, 2013.
  10. KAHDRA A., PINELLI E., LACROIX MZ., BOUSQUET-MELOU A., HAMDI H., MERLINA G., GUIRESSE M. and HAFIDI M. Assessment of the genotoxicity of Quinolones-1 contaminated soil with the Vicia faba micronucleus test.

    Ecotox. Environ. Safe., 76, 187-192, 2012.
  11. BOUSQUET-MELOU A., P. JACQUIET, H. HOSTE, J. CLEMENT, J-P. BERGEAUD, M. ALVINERIE and P.-L. TOUTAIN. Licking behaviour induces partial anthelmintic efficacy of ivermectin pour-on formulation in untreated cattle.

    Int. J. Parasitol., 41, 563-569, 2011.
    article en ligne
    Impact of early versus later fluoroquinolone treatment on the clinical, microbiological and resistance outcomes in a mouse-lung model of Pasteurella multocida infection.

    Vet. Microbiol., 148, 292-297, 2011.
    article en ligne
  13. MATHON D.H., S. PALIERNE, P. MEYNAUD-COLLARD, C. LAMOUR-LAYSSOL, A. FERRIERES-DULAURENT, A. COLSON, M. LACROIX, A. BOUSQUET-MELOU, M. DELVERDIER and A.AUTEFAGE. Laparoscopic-Assisted Colopexy and Sterilization in Male Dogs: Short-term Results and Physiologic Consequences.

    Vet. Surg., 40, 500-508, 2011.
    Emergence of resistant Klebsiella pneumoniae in the intestinal tract during a successful treatment of Klebsiella pneumoniae lung infection in rats.

    Antimicrob. Agents Chemother., 54, 2960-2964, 2010.
    article en ligne
  15. KESTEMAN A-S., A.A. FERRAN, P-L., A. PERRIN-GUYOMARD, M. LAURENTIE, P. SANDERS, P-L. TOUTAIN and A. BOUSQUET-MELOU. Influence of Inoculum Size and Marbofloxacin Plasma Exposure on the Amplification of Resistant Subpopulations of Klebsiella pneumoniae in a Rat Lung Infection Model.

    Antimicrob. Agents Chemother., 53, 4740-4748, 2009. article en ligne
  16. FERRAN A.A., A-S KESTEMAN, P-L TOUTAIN and A. BOUSQUET-MELOU. Pharmacokinetic/Pharmacodynamic Analysis of the Influence of Inoculum Size on the Selection of Resistance in Escherichia coli by a Quinolone in a Mouse Thigh Bacterial Infection Model.

    Antimicrob. Agents Chemother., 53, 3384-3390, 2009. article en ligne
  17. BIBBAL D., V. DUPOUY, M.F. PRERE, P.-L. TOUTAIN and A. BOUSQUET-MELOU. Relatedness of Escherichia coli with different susceptibility phenotypes isoltaed from swine feces during an ampicillin treatment.

    Appl. Environ. Microbiol., 75, 2999-3006, 2009. article en ligne
  18. VANDENBROUCKE V., A. BOUSQUET-MELOU, P. DE BACKER and S. CROUBELS. Pharmacokinetics of eight anticoagulant rodenticides in mice after single oral administration.

    J. vet. Pharmacol. Therap., 31, 437-445, 2008. article en ligne
  19. LAFFORGUE G., C. ARELLANO, C. VACHOUX, J. WOODLEY, C. PHILIPBERT, V. DUPOUY, A. BOUSQUET-MELOU, P. GANDIA and G. HOUIN. Oral absorption of ampicillin: role of the paracellular route versus the PepT1 transporter.

    Fundam. Clin. Pharmacol., 22, 189-201, 2008. article en ligne
  20. PASMANS F., K. BAERT, A. MARTEL, A. BOUSQUET-MELOU, R. LANCKRIET, S. DE BOEVER, F. VAN IMMERSEEL, V. EECKHAUT, P. DE BACKER, and F. HAESEBROUCK. Iduction of the carrier state in pigeons infected with Salmonella enterica subspecies enterica serovar Typhimurium PT99 by treatment with florfenicol: a matter of pharmacokinetics.

    Antimicrob. Agents Chemother., 52, 954-961, 2008. article en ligne
  21. TOUTAIN P.-L., A. BOUSQUET-MELOU and M. MARTINEZ. AUC/MIC: A PK/PD index for antibiotics with a time dimension or simply a dimensionless scoring factor?

    J. Antimicrob. Chemother., 60, 1185-1188, 2007. article en ligne
  22. FERRAN A., V. DUPOUY, P.-L. TOUTAIN and A. BOUSQUET-MELOU. Influence of Inoculum Size on the Selection of Escherichia coli Resistant Mutants in Relation to Mutant Preventive Concentrations of Marbofloxacin.

    Antimicrob. Agents Chemother., 51, 4163-4166, 2007. article en ligne
  23. LALLEMAND E., A. LESPINE, M. ALVINERIE, A. BOUSQUET-MELOU and P.-L. TOUTAIN. Estimation of absolute bioavailability of moxidectin in dogs using a semi-simultaneous ùethod : influence of lipid co-administration.

    J. vet. Pharmacol. Therap., 30, 375-80, 2007. article en ligne
  24. BIBBAL D., V. DUPOUY, J.P. FERRE, P.-L. TOUTAIN, O. FAYET, M.F. PRERE and A. BOUSQUET-MELOU. Impact of three ampicillin dosage regimens on selection of ampicillin resistance in Enterobacteriaceae and excretion of blaTEM genes in swine feces.

    Appl. Environ. Microbiol., 73, 4785-4790, 2007. article en ligne
  25. PEYROU M., A. BOUSQUET-MELOU, V. LAROUTE, A. VRINS and M.Y. DOUCET. Enrofloxacin and marbofloxacin in horses: comparison of pharmacokinetic parameters, use of urinary and metabolite data to estimate first-pass efect and absorbed fraction.

    J. vet. Pharmacol. Therap., 29, 337-344, 2006. article en ligne
  26. BOUSQUET-MELOU A., E. FORMENTINI, N. PICARD-HAGEN, L. DELAGE, V. LAROUTE and P.-L. TOUTAIN. The Adrenocorticotropin Stimulation Test: Contribution of a Physiologically Based Model Developed in Horse for Its Interpretation in Different Pathohysiological Situations Encountered in Man.

    Endocrinology, 147, 4281-4291, 2006. article en ligne (supplemental data)
  27. LESPINE A., G. CHANOIT, A. BOUSQUET-MELOU, E. LALLEMAND, F. BASSISSI, M. ALVINERIE and P.L. TOUTAIN. Contribution of lymphatic transport to the systemic exposure of orally administered moxidectin in conscious lymph duct-cannulated dogs.

    Eur. J. Pharm. Sci., 27, 37-43, 2006. article en ligne
  28. DIQUELOU A., C. BARBASTE, A.M. GABAIG, C. TRUMEL, N. ABELLA-BOURGES, J-F. GUELFI and A. BOUSQUET-MELOU. Pharmacokinetics and pharmacodynamics of a therapeutic dose of unfractionated heparin (200 U/kg) administered subcutaneously or intravenously to healthy dogs.

    Vet. Clin. Pathol., 34, 237-242, 2005.
  29. PEYROU M., M.Y. DOUCET, A. VRINS, M. SCHNEIDER, D. CONCORDET and A. BOUSQUET-MELOU. Population pharmacokinetics of marbofloxacin in horses: preliminary analysis.

    J. vet. Pharmacol. Therap., 27, 283-288, 2004. article en ligne
  30. BOUSQUET-MÉLOU A., S. MERCADIER, M. ALVINERIE and P.L. TOUTAIN. Endectocide exchanges between grazing cattle after pour-on administration of doramectin, ivermectin and moxidectin.

    Int. J. Parasitol., 34, 1299-1307, 2004. article en ligne
  31. LAFFONT C.M., A. BOUSQUET-MÉLOU, D. BRALET, M. ALVINERIE, J. FINK-GREMMELS and P.L. TOUTAIN. A pharmacokinetic model to document the actual disposition of topical ivermectin in cattle.

    Vet. Res., 34, 445-460, 2003. article en ligne
  32. BOUSQUET-MÉLOU A., C.M. LAFFONT, V. LAROUTE and P.L. TOUTAIN. Modelling the loss of metabolic capacities of cultured hepatocytes – Application to measurement of Michaelis-Menten kinetic parameters in in vitro systems.

    Xenobiotica, 32, 895-906, 2002. article en ligne
  33. BOUSQUET-MÉLOU A., S. BERNARD, M. SCHNEIDER and P.L. TOUTAIN. Pharmacokinetics of marbofloxacin in horses.

    Equine vet J., 34, 366-372, 2002. article en ligne
  34. LAFFONT C.M., P.L. TOUTAIN, M. ALVINERIE, and A. BOUSQUET-MÉLOU. Intestinal secretion is a major route for parent ivermectin elimination in the rat.

    Drug Metab. Dispos., 30, 626-630, 2002. article en ligne
  35. LAFFONT C.M., M. ALVINERIE, A. BOUSQUET-MÉLOU and P.L. TOUTAIN. Licking behaviour and environmental contamination arising from pour-on ivermectin for cattle.

    Int. J. Parasitol., 31, 1687-1692, 2001. article en ligne
  36. PICARD-HAGEN N., V. GAYRARD, M. ALVINERIE , H. SMEYERS, R. RICOU, A. BOUSQUET-MÉLOU and P.L. TOUTAIN. A non-labelled method to evaluate cortisol production rate by modeling plasma CBG-free cortisol disposition.

    Am. J. Physiol., 281, E946-E956, 2001. article en ligne
  37. BOUSQUET-MÉLOU A., C. MUÑOZ, J. GALITZKY, M. BERLAN and M. LAFONTAN. Pregnancy modifies the alpha2-beta functional balance in rabbit fat cells.

    J. Lipid Res., 40, 267-274, 1999. article en ligne
  38. VIGUERIE-BASCANDS N., A. BOUSQUET-MÉLOU, J. GALITZKY, D. LARROUY, M. BERLAN and L. CASTEILLA. Evidence for numerous brown adipocytes lacking functional ß3-adrenoceptors in fat pads from non-human primates.

    J. Clin. Endocrinol. Metab., 81, 368-375, 1996. article en ligne
  39. BOUSQUET-MÉLOU A., J. GALITZKY, C. MUÑOZ MORENO, M. BERLAN and M. LAFONTAN. Desensitization of ß-adrenergic responses in adipocytes involves receptor subtypes and cyclicAMP phosphodiesterase.

    Eur. J. Pharmacol. – Mol. Pharmacol. Sect., 289, 235-247, 1995. article en ligne
  40. BOUSQUET-MÉLOU A., J. GALITZKY, M. LAFONTAN and M. BERLAN. Control of lipolysis in intra-abdominal fat cells of non-human primates: comparison with humans.

    J. Lipid Res., 36, 451-461, 1995. article en ligne
  41. BOUSQUET-MÉLOU A., J. GALITZKY, C. CARPÉNÉ, M. LAFONTAN and M. BERLAN. ß-Adrenergic control of lipolysis in primate white fat cells: a comparative study with nonprimate mammals.

    Am. J. Physiol., 267, R115-R123, 1994. article en ligne
  42. BERLAN M., J. GALITZKY, A. BOUSQUET-MÉLOU, M. LAFONTAN and J-L. MONTASTRUC. Beta-3 Adrenoceptor-Mediated Increase in Cutaneous Blood Flow in the Dog.

    J. Pharmacol. Exp. Ther., 268, 1444-11451, 1994. article en ligne
  43. TAVERNIER G., J. GALITZKY, A. BOUSQUET-MÉLOU, J-L. MONTASTRUC and M. BERLAN. The Positive Chronotropic Effect Induced by BRL 37344 and CGP 12177, Two Beta-3 Adrenergic Agonists, Does Not Involve Cardiac Beta Adrenoceptors but Baroreflex Mechanisms.

    J. Pharmacol. Exp. Ther., 263, 1083-1090, 1992. article en ligne
  44. BLANCHARD M. M., C.G. GOODYER, J. CHARRIER, G.KANN, R. GARCIA-VILLAR, A. BOUSQUET-MÉLOU, P.L. TOUTAIN and B. BARENTON. GRF treatment of late pregnant ewes alters maternal and fetal somatotropic axis activity.

    Am. J. Physiol., 260, E575-E580, 1991. article en ligne


  1. TOUTAIN P.L. and A. BOUSQUET-MÉLOU. Rebuttal to the reaction of the EGGVP to the review article ‘the consequences of generic marketing on antibiotic consumption and the spread of microbial resistance: the need for new antibiotics.

    J. vet. Pharmacol. Therap., 37, 618-623, 2014.
  2. TOUTAIN P.L. and A. BOUSQUET-MÉLOU. The consequences of generic marketing on antibiotic consumption and the spread of microbial resistance: the need for new antibiotics.

    J. vet. Pharmacol. Therap., 36, 420-424, 2013.
  3. CARLET J., C. RAMBAUD, C. PULCINI & l’Alliance contre le développement des bactéries multi-résistantes (ACdeMR). Alliance against MDRO: safeguarding antibiotics.

    Ann. Fr. Anesth. Reanim., 31, 704-708, 2012.
  4. TOUTAIN P.L., S. MODRIC, A. BOUSQUET-MÉLOU, JM SALLOVITZ & C. LANUSSE. Should licking behavior be considered in the bioavailability evaluation of transdermal products?

    J. vet. Pharmacol. Therap., 35 (suppl. 1), 39-43, 2012.
  5. TOUTAIN P.L., A. FERRAN A. and A. BOUSQUET-MÉLOU. Species Differences in Pharmacokinetics and pharmacodynamics.

    Handb. Exp. Pharmacol., 199, 19-48, 2010.
  6. TOUTAIN P.L. and A. BOUSQUET-MÉLOU. Guest Editorial. New antibiotics in orphan food-producing animals: What is the responsibility of a Journal regarding good veterinary practice?

    Vet. J., 179, 155-157, 2009.
  7. TOUTAIN P.L. and A. BOUSQUET-MÉLOU. Bioavailability and its assessment.

    J. vet. Pharmacol. Therap., 27, 455-466, 2004.
  8. TOUTAIN P.L. and A. BOUSQUET-MÉLOU. Volumes of distribution.

    J. vet. Pharmacol. Therap., 27, 441-453, 2004.
  9. TOUTAIN P.L. and A. BOUSQUET-MÉLOU. Plasma terminal half-life.

    J. vet. Pharmacol. Therap., 27, 427-439, 2004.
  10. TOUTAIN P.L. and A. BOUSQUET-MÉLOU. Plasma clearance.

    J. vet. Pharmacol. Therap., 27, 415-425, 2004.
  11. TOUTAIN P.L., J.R.E. DEL CASTILLO and A. BOUSQUET-MÉLOU. The pharmacokinetic-pharmacodynamic (PK/PD) approach to a rational dosage regimen for antibiotics.

    Res. Vet. Sci., 73, 105-114, 2002.
  12. TOUTAIN P.L. and A. BOUSQUET-MÉLOU. Free drug fraction vs. free drug concentration : a matter of frequent confusion.

    J. vet. Pharmacol. Therap., 25, 460-463, 2002.
  13. BOUSQUET-MÉLOU A. and P.L. TOUTAIN. Letter to the Editor. Comments on « Effects of altered plasma alpha1-acid glycoprotein levels on pharmacokinetics of some basic antibiotics in pigs: simulation analysis ».

    J. vet. Pharmacol. Therap., 25, 239, 2002.
  14. TOUTAIN P.L., H.P. LEFEBVRE and A. BOUSQUET-MÉLOU. Relevance of kinetic concepts to interpret a plasma concentration in clinical biochemistry.

    Rev. Med. Vet., 151, 643-648, 2000.
  15. CARPÉNÉ C., A. BOUSQUET-MÉLOU, J. GALITZKY, M. BERLAN and M. LAFONTAN. Lipolytic effect of beta1-, beta2- and beta3-adrenergic agonists in white adipose tissue of mammals.

    Ann. N.Y. Acad. Sci., 839, 186-189, 1998.
  16. LAFONTAN M., P. BARBE, J. GALITZKY, G. TAVERNIER , D. LANGIN, C. CARPÉNÉ, A. BOUSQUET-MÉLOU and M. BERLAN. Adrenergic regulation of adipocyte metabolism.

    Hum. Reprod., 12(suppl. 1), 6-16, 1997.
  17. LAFONTAN M., A. BOUSQUET-MÉLOU, J. GALITZKY, P. BARBE, C. CARPÉNÉ, D. LANGIN, M. BERLAN, P. VALET, I. CASTAN, A. BOULOUMIÉ, J-S. SAULNIER-BLACHE. Adrenergic Receptors and Fat Cells: Differential Recruitment by Physiological Amines and Homologous Regulation.

    Obes. Res., 3(suppl. 4), 507S-514S, 1995.
  18. GALITZKY J., C. CARPÉNÉ, A. BOUSQUET-MÉLOU, M. BERLAN and M. LAFONTAN. Differential Recruitment of ß1-, ß2- and ß3-Adrenoceptors in White and Brown Adipocytes.

    Fundam. Clin. Pharmacol., 9, 324-331, 1995.
  19. BERLAN M., P. BARBE, V.STICH, J. GALITZKY, A. BOUSQUET-MÉLOU et M. LAFONTAN. Lipomobilisation, aspects physiopathologiques et pharmacologiques. Ann. Endocrinol., 56, 97-100, 1995.
  20. BOUSQUET-MELOU A. et P.L. TOUTAIN. Les extrapolations posologiques.

    Rec. Méd. Vét., 166, 3, 239-249, 1990.